Extended release delivery system of metoprolol succinate using hot-melt extrusion: effect of release modifier on methacrylic acid copolymer
نویسندگان
چکیده
منابع مشابه
In Vitro Evaluation of Oral Extended Release Drug Delivery System for Metoprolol Succinate Using Kollidon SR
The objective of this study was to develop a sustained release matrix tablet Metoprolol Succinate by cost saving and production efficient process. Among various tablet manufacturing process, direct compression is the simplest and cost saving process. Different trials were formulated and evaluated using different concentrations of directly compressible grade Kollidon SR as release retardant. The...
متن کاملMetoprolol succinate extended release/hydrochlorothiazide combination tablets
Lowering elevated blood pressure (BP) with drug therapy reduces the risk for catastrophic fatal and nonfatal cardiovascular events such as stroke and myocardial infarction. Given the heterogeneity of hypertension as a disease, the marked variability in an individual patient's BP response, and low response rates with monotherapy, expert groups such as the Joint National Committee (JNC) emphasize...
متن کاملDesign and Optimisation of Extended Release Metoprolol Succinate Formulation Using Melt Granulation Technique
Metoprolol succinate (M.succinate), a BCS Class I drug is the most widely prescribed anti-hypertensive drug and is considered to be safe. Owing to its high solubility, fabrication of an extended release matrix formulation becomes extremely challenging. Hydrophilic matrix polymers are the preferred systems for developing an extended release formulation. However, for highly soluble drugs, it fail...
متن کاملEffect of Processing and Polymer Variables on Invitro Release of Metoprolol Succinate Extended Release Tablets
The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5c...
متن کاملDevelopment of extended release matrices of rifampicin using hot melt extrusion technique
Article history: Received on: 12/06/2013 Revised on: 16/09/2013 Accepted on: 17/10/2013 Available online: 31/10/2013 Tuberculosis has metamorphosized over the decades from drug resistant to multidrug resistant to the lethal extensively drug resistant forms lately. With scarce newer anti-TB drugs emerging, there is a pressing need to ameliorate the current treatment therapy by modulating the for...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2018
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-018-0545-1